Top 5 DeSci Projects Transforming Scientific Research in 2025

Welcome to this mini-guide showcasing the most impactful projects in the world of DeSci (Decentralized Science). Although still a relatively new movement, DeSci is quickly becoming essential in saving today’s healthcare systems and revolutionizing science as we know it. This guide will give you a clearer picture of this Web3-powered field, one that’s sure to define how future generations engage with science and health.

DeSci offers a new approach to science

Science continues to make progress through discoveries—but it could go much faster.

Why? Because today’s scientific ecosystem is largely centralized. Research lies in the hands of a few powerful players (governments, corporations, academic publishers), raising questions around governance, access, and transparency.

DeSci aims to fix that. It promises a transparent, collaborative, and community — driven approach to science — where research results are open and accessible to any scientist, institution, or individual who needs them.

The ultimate goal: to accelerate scientific and medical progress, improve global health, and reduce healthcare costs. A virtuous circle in motion.

DeSci reinvents the way we fund, govern, and share science, through:

• DAOs (Decentralized Autonomous Organizations) to fund research initiatives
• Tokenized intellectual property and open-access publications with built-in incentives
• EHRs (Electronic Health Records) connected to citizen-led communities

So, where does the movement stand in 2025? Who are the key players and what are they actually doing?

Here’s a detailed look at the Top 5 DeSci projects transforming science in 2025 and 2026—with real funding, open portfolios, operational calls for proposals, and active platforms.

1/ VitaDAO — the longevity DAO that funds, publishes and monitors projects

What does VitaDAO offer?

VitaDAO is a DAO (Decentralized Autonomous Organization) dedicated to longevity sciences: it identifies translational research opportunities and funds teams via Web3 mechanisms, with a public project wallet. Several million dollars have been deployed and about twenty projects funded, with transparency on treasury and governance.

How does it work?

Researchers apply, a dealflow evaluates, then the community votes and funds; monitoring is then published (blogs, governance forum). Indicators displayed on the site (funds deployed, projects, community) make it one of the few DeSci cases with consolidated and sustainable reporting.

Why join the project?

If you are fascinated by longevity-related questions, and if open funding and IP (Intellectual Property) transfer to biotechs interest you.

2/ Galeon — The DAO bringing together healthcare professionals and patients

What does Galeon offer?

French project Galeon has one mission: accelerate scientific research by standardizing and securing hospital data. Through its robust EHR software, it creates a reliable foundation for Population Health Management and proactive care.

On top of this, Galeon builds a community-driven layer with its DAO and gamified platform Atlantis. Here, patients, providers, and contributors can participate in research and value-sharing via the $GALEON token—a true bridge between hospitals, caregivers, patients, and citizens.

How does it work?

Galeon’s EHR uses AI and blockchain to structure and secure sensitive medical data. Deployed in nearly 20 French hospitals, it ensures interoperability between institutions. Its proprietary tech allows decentralized AI training on vast amounts of anonymized data.

Meanwhile, Atlantis brings together a community of “Pioneers” engaging in quests, project support, and governance.

Why join the project?

If you care about hospital interoperability, medical AI, or grassroots DeSci from the patient’s bedside—and want to support structured research while safeguarding data privacy—Galeon is for you.

3/ Molecule — The IP-NFT/IP-Tokens infrastructure that “industrialized” on-chain Intellectual Property

What does Molecule offer?

Molecule offers an infrastructure that “packages” Intellectual Property assets or “IP” (patents, datasets, licensing agreements) into IP-NFTs, and can fractionalize them into IP-Tokens to fund, govern and transfer these rights more efficiently (IP = Intellectual Property). It is a component used by several BioDAOs (like VitaDAO, AthenaDAO…).

How does it work?

Founding case: first biopharma IP-NFT sold to VitaDAO in August 2021, demonstrating on-chain transferability of a university license agreement — a historic milestone of DeSci. Since then, Molecule documents iterations (IP-NFT v2) and collaborations.

Why join the project?

If you are interested in IP tokenization, research asset markets and shared governance of scientific outcomes.

4/ ResearchHub — an open publication “economy” with paid reviews

What does ResearchHub offer?

ResearchHub builds a publishing and reviewing platform where contributions (summaries, reviews, bounties, DOIs for Digital Object Identifiers) are incentivized by the RSC token. The goal: accelerate the dissemination of reproducible work while paying reviewers and facilitating micro-funding.

How does it work?

Users create bounties (e.g.: peer-review of a preprint) and are paid in RSC tokens according to public scales; documentation details typical amounts and token usage framework. Activity is visible via the foundation and updated documents.

Why join the project?

If you are interested in pragmatic open science, paid reviewing and micro-grants directly linked to scientific tasks.

5/ AthenaDAO — DeSci dedicated to women’s health (cohorts & first IP-NFT)

What does AthenaDAO offer?

AthenaDAO focuses DeSci funding on women’s health (reproductive longevity, ReproTech, etc.). The project financed a first IP-NFT and regularly announces collaborations and calls for projects, with clear communication (website, Substack, press kit).

How does it work?

The mechanism combines calls for projects (e.g.: Cohort 4 open on ReproTech), selection by the DAO, then funding (grants/IP-NFT) and quarterly reporting. The first aggregated financial commitments (> $250k in the initial phase) have been publicly detailed.

Why join this project?

If you are passionate about biomedical research centered on women’s needs, reproductology and open innovation serving a long-underfunded field.

These five projects are at the forefront of DeSci, shaping a new scientific ecosystem that’s more inclusive, open, and effective. Many more are emerging, and as funding grows, the dream of decentralized science is becoming a tangible, collective reality.